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Decarboxylative Conjunctive Cross‐coupling of Vinyl Boronic Esters using Metallaphotoredox Catalysis.
- Source :
- Angewandte Chemie International Edition; 3/9/2020, Vol. 59 Issue 11, p4375-4379, 5p
- Publication Year :
- 2020
-
Abstract
- The synthesis of complex alkyl boronic esters through conjunctive cross‐coupling of vinyl boronic esters with carboxylic acids and aryl iodides is described. The reaction proceeds under mild metallaphotoredox conditions and involves an unprecedented decarboxylative radical addition/cross‐coupling cascade of vinyl boronic esters. Excellent functional‐group tolerance is displayed, and application of a range of carboxylic acids, including secondary α‐amino acids, and aryl iodides provides efficient access to highly functionalized alkyl boronic esters. The decarboxylative conjunctive cross‐coupling was also applied to the synthesis of sedum alkaloids. [ABSTRACT FROM AUTHOR]
- Subjects :
- BORONIC esters
ARYL iodides
CATALYSIS
CARBOXYLIC acids
ESTERS
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 59
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 141996781
- Full Text :
- https://doi.org/10.1002/anie.201916340