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Decarboxylative Conjunctive Cross‐coupling of Vinyl Boronic Esters using Metallaphotoredox Catalysis.

Authors :
Mega, Riccardo S.
Duong, Vincent K.
Noble, Adam
Aggarwal, Varinder K.
Source :
Angewandte Chemie International Edition; 3/9/2020, Vol. 59 Issue 11, p4375-4379, 5p
Publication Year :
2020

Abstract

The synthesis of complex alkyl boronic esters through conjunctive cross‐coupling of vinyl boronic esters with carboxylic acids and aryl iodides is described. The reaction proceeds under mild metallaphotoredox conditions and involves an unprecedented decarboxylative radical addition/cross‐coupling cascade of vinyl boronic esters. Excellent functional‐group tolerance is displayed, and application of a range of carboxylic acids, including secondary α‐amino acids, and aryl iodides provides efficient access to highly functionalized alkyl boronic esters. The decarboxylative conjunctive cross‐coupling was also applied to the synthesis of sedum alkaloids. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14337851
Volume :
59
Issue :
11
Database :
Complementary Index
Journal :
Angewandte Chemie International Edition
Publication Type :
Academic Journal
Accession number :
141996781
Full Text :
https://doi.org/10.1002/anie.201916340