Roadmap for research on individual radiosensitivity and radiosusceptibility – the MELODI view on research needs.

Roadmap for research on individual radiosensitivity and radiosusceptibility - the MELODI view on research needs The workshop covered three topics: (1) Clinical and epidemiological observations, (2) Mechanisms involved in individual radiation response, and (3) Tests for individual radiosensitivity/susceptibility to identify sensitive and susceptible subgroups both for cancer and non-cancer diseases. Patients with mutations in these response pathways have been identified and display a marked radiosensitivity but they represent only a small percentage of the radiotherapy (RT) patients with adverse reactions. Patients with mutations in the DNA damage response pathway display marked radiosensitivity but they represent only a small percentage of the RT patients with adverse reactions. [Extracted from the article]