Open Models for Clinical Pharmacology.

Computational models incorporating molecular, cellular, and physiological mechanisms (i.e., quantitative systems pharmacology (QSP)) are gaining traction as predictive tools in drug development. While MATLAB (MathWorks, Natick, MA) and its dependent SimBiology are the most common, at least a dozen other software packages are in use and active development.[6] Considerable time and resources are spent developing this plethora of software. Moreover, without efforts to maintain compatibility (i.e., enabling software to read/write models in a standard format such as SBML or pharmML) the science could become balkanized by incompatible software. [Extracted from the article]