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Effects of occlusion modification on the remodelling of degenerative mandibular condylar processes.
- Source :
- Oral Diseases; Apr2020, Vol. 26 Issue 3, p597-608, 12p, 1 Diagram, 1 Chart, 6 Graphs
- Publication Year :
- 2020
-
Abstract
- Objective: The temporomandibular joint (TMJ) displays a high remodelling capability in response to occlusion changes. The purpose of the current study was to investigate the responses of TMJ condyles of growing mice to the installation of a unilateral anterior crossbite (UAC) prosthesis and the replacement of the UAC prothesis with a bilateral anterior elevation (BAE) prosthesis. Materials and Methods: C57BL/6J mice were randomly assigned to the blank control and experimental groups. In mice in the experimental groups, UAC was created, while in others, BAE was created after the creation of UAC or removal of UAC. Changes in TMJ condylar cartilage and subchondral bone were assessed. Results: The degradation of condylar cartilage induced by UAC was reversed by BAE, as evaluated by cartilage histochemical changes, collagen II‐positive area, collagen X‐positive chondrocytes and expression levels of Adamts‐5, Mmp13, Tnf‐α and Il‐1β. Subchondral bone was assessed based on the subchondral bone volume, the number of TRAP‐positive cells and the Opg/Rankl ratio. Conclusion: The growing mouse TMJ condyle displays a high remodelling capability, which can be degenerative or rehabilitative in response to the creation of UAC and the replacement of UAC with BAE. Early correction of occlusion is beneficial for the recovery of degenerative condyles. [ABSTRACT FROM AUTHOR]
- Subjects :
- BONE remodeling
ANIMAL experimentation
ARTHROPLASTY
ARTICULAR cartilage
CARTILAGE cells
COLLAGEN
CONVALESCENCE
CYTOCHEMISTRY
DENTAL implants
MALOCCLUSION
MANDIBULAR condyle
MICE
ORAL surgery
TEMPOROMANDIBULAR joint
TEMPOROMANDIBULAR disorders
BONE density
TREATMENT effectiveness
EARLY medical intervention
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 1354523X
- Volume :
- 26
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Oral Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 142538468
- Full Text :
- https://doi.org/10.1111/odi.13274