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Heart Failure Is a Risk Factor for Suffering and Dying of Clostridium difficile Infection. Results of a 15-Year Nationwide Study in Spain.

Authors :
Méndez-Bailón, Manuel
Jiménez-García, Rodrigo
Hernández-Barrera, Valentín
de Miguel-Díez, Javier
de Miguel-Yanes, José M.
Muñoz-Rivas, Nuria
Lorenzo-Villalba, Noel
Carabantes-Alarcon, David
Zamorano-León, José J.
Astasio-Arbiza, Paloma
Ortega-Molina, Paloma
López-de-Andrés, Ana
Source :
Journal of Clinical Medicine; Mar2020, Vol. 9 Issue 3, p614, 1p
Publication Year :
2020

Abstract

Background: We aimed to (1) analyze time trends in the incidence and in-hospital outcomes of heart failure (HF) patients suffering Clostridioides difficile infection (CDI); (2) compare clinical characteristics of CDI patients between those with HF and matched non-HF patients; and (3) identify predictors of in-hospital mortality (IHM) among HF patients suffering CDI. Methods: Retrospective study using the Spanish National Hospital Discharge Database from 2001 to 2015. Patients of age ≥40 years with CDI were included. For each HF patient, we selected a year, age, sex, and readmission status-matched non-HF patient. Results: We found 44,695 patients hospitalized with CDI (15.46% with HF). HF patients had a higher incidence of CDI (202.05 vs. 145.09 per 100,000 hospitalizations) than patients without HF (adjusted IRR 1.35; 95% CI 1.31–1.40). IHM was significantly higher in patients with HF when CDI was coded as primary (18.39% vs. 7.63%; p < 0.001) and secondary diagnosis (21.12% vs. 14.76%; p < 0.001). Among HF patient's predictor of IHM were older age (OR 8.80; 95% CI 2.55–20.33 for ≥85 years old), those with more comorbidities (OR 1.68; 95% CI 1.12–2.53 for those with Charlson Comorbidity index ≥2), and in those with severe CDI (OR 6.19; 95% CI 3.80–10.02). Conclusions: This research showed that incidence of CDI was higher in HF than non-HF patients. HF is a risk factor for IHM after suffering CDI. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20770383
Volume :
9
Issue :
3
Database :
Complementary Index
Journal :
Journal of Clinical Medicine
Publication Type :
Academic Journal
Accession number :
142543372
Full Text :
https://doi.org/10.3390/jcm9030614