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The ectodomain shedding of CD30 is specifically regulated by peptide motifs in its cysteine-rich domains 2 and 5.
- Source :
- FASEB Journal; May2004, Vol. 18 Issue 7, p893-895, 3p, 2 Diagrams, 2 Graphs
- Publication Year :
- 2004
-
Abstract
- Focuses on the shedding-influencing role of structural elements of the ectodomain of CD30, a known substrate of tumor necrosis factorα-converting enzyme. Antibody-dependent inhibition of CD30 shedding; Regulation of the releasing enzyme in a feedback fashion by the soluble product through competitive inhibition; Modulation of sCD30 release by the cleavage product.
- Subjects :
- TUMOR necrosis factors
CYTOKINES
GROWTH factors
ENZYMES
ENZYMOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 08926638
- Volume :
- 18
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- FASEB Journal
- Publication Type :
- Academic Journal
- Accession number :
- 14265612
- Full Text :
- https://doi.org/10.1096/fj.03-0901fje