Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic β-cells.

Discusses the findings of a study on the impact of glucose routing through hexosamine biosynthesis pathway on β-cells survival. Effects of high glucose and glucosamine on human pancreatic β-cell survival; Influence of glucosamine on O-glycosylation of insulin receptor on RIN β-cells; Clinical significance of the study.