Back to Search
Start Over
Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic β-cells.
- Source :
- FASEB Journal; Jun2004, Vol. 18 Issue 9, p959-961, 3p, 1 Color Photograph, 1 Diagram
- Publication Year :
- 2004
-
Abstract
- Discusses the findings of a study on the impact of glucose routing through hexosamine biosynthesis pathway on β-cells survival. Effects of high glucose and glucosamine on human pancreatic β-cell survival; Influence of glucosamine on O-glycosylation of insulin receptor on RIN β-cells; Clinical significance of the study.
- Subjects :
- GLUCOSE
PANCREATIC beta cells
HEXOSAMINES
BIOSYNTHESIS
GLUCOSAMINE
GLYCOSYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 08926638
- Volume :
- 18
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- FASEB Journal
- Publication Type :
- Academic Journal
- Accession number :
- 14265656
- Full Text :
- https://doi.org/10.1096/fj.03-0725fje