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Radiobiological Implications of Nanoparticles Following Radiation Treatment.

Authors :
Ahmad, Reem
Schettino, Giuseppe
Royle, Gary
Barry, Miriam
Pankhurst, Quentin A.
Tillement, Olivier
Russell, Ben
Ricketts, Kate
Source :
Particle & Particle Systems Characterization; Apr2020, Vol. 37 Issue 4, p1-10, 10p
Publication Year :
2020

Abstract

Materials with a high atomic number (Z) are shown to cause an increase in the level of cell kill by ionizing radiation when introduced into tumor cells. This study uses in vitro experiments to investigate the differences in radiosensitization between two cell lines (MCF‐7 and U87) and three commercially available nanoparticles (gold, gadolinium, and iron oxide) irradiated by 6 MV X‐rays. To assess cell survival, clonogenic assays are carried out for all variables considered, with a concentration of 0.5 mg mL−1 for each nanoparticle material used. This study demonstrates differences in cell survival between nanoparticles and cell line. U87 shows the greatest enhancement with gadolinium nanoparticles (2.02 ± 0.36), whereas MCF‐7 cells have higher enhancement with gold nanoparticles (1.74 ± 0.08). Mass spectrometry, however, shows highest elemental uptake with iron oxide and U87 cells with 4.95 ± 0.82 pg of iron oxide per cell. A complex relationship between cellular elemental uptake is demonstrated, highlighting an inverse correlation with the enhancement, but a positive relation with DNA damage when comparing the same nanoparticle between the two cell lines. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09340866
Volume :
37
Issue :
4
Database :
Complementary Index
Journal :
Particle & Particle Systems Characterization
Publication Type :
Academic Journal
Accession number :
142724903
Full Text :
https://doi.org/10.1002/ppsc.201900411