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No association of the mitochondrial DNA A12308G polymorphism with increased risk of stroke in patients with the A3243G mutation.
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry; Aug2004, Vol. 75 Issue 8, p1204-1205, 2p
- Publication Year :
- 2004
-
Abstract
- This article focuses on a study that finds no association of the mitochondrial DNA A 12308G polymorphism with increased risk of stroke in patients with the A3242G mutation. Only 50% of patients carrying the A3243G mutation have stroke-like episodes and the reason for this clinical variability remains poorly understood. It is responsible for 80% of cases of MELAS, mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes, and is also associated with several other phenotypes including maternally inherited diabetes and deafness and chronic progressive external ophthalmoplegia. Researchers carried out a large, multicentre study to investigate the A12308G polymorphism in a group of 107 unrelated family index cases harbouring the A3243G mutation.
- Subjects :
- EYE paralysis
MITOCHONDRIA
DNA
CEREBROVASCULAR disease
DIABETES
ACIDOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00223050
- Volume :
- 75
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 14274683
- Full Text :
- https://doi.org/10.1136/jnnp.2003.026278