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Tcf1+ cells are required to maintain the inflationary T cell pool upon MCMV infection.
- Source :
- Nature Communications; 5/8/2020, Vol. 11 Issue 1, p1-14, 14p
- Publication Year :
- 2020
-
Abstract
- Cytomegalovirus-based vaccine vectors offer interesting opportunities for T cell-based vaccination purposes as CMV infection induces large numbers of functional effector-like cells that accumulate in peripheral tissues, a process termed memory inflation. Maintenance of high numbers of peripheral CD8 T cells requires continuous replenishment of the inflationary T cell pool. Here, we show that the inflationary T cell population contains a small subset of cells expressing the transcription factor Tcf1. These Tcf1<superscript>+</superscript> cells resemble central memory T cells and are proliferation competent. Upon sensing viral reactivation events, Tcf1<superscript>+</superscript> cells feed into the pool of peripheral Tcf1<superscript>−</superscript> cells and depletion of Tcf1<superscript>+</superscript> cells hampers memory inflation. TCR repertoires of Tcf1<superscript>+</superscript> and Tcf1<superscript>−</superscript> populations largely overlap, with the Tcf1<superscript>+</superscript> population showing higher clonal diversity. These data show that Tcf1<superscript>+</superscript> cells are necessary for sustaining the inflationary T cell response, and upholding this subset is likely critical for the success of CMV-based vaccination approaches. Upon infection with cytomegalovirus, CD8<superscript>+</superscript> T cells undergo prolific expansion in a process known as memory inflation. Here the authors define a population of Tcf1 expressing cells within the inflationary pool that is critical in fuelling this process. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- 143113468
- Full Text :
- https://doi.org/10.1038/s41467-020-16219-3