Synthesis and structure of ethyl 2-[(4-oxo-3-phenyl- 3,4-dihydroquinazolin-2-yl)sulfanyl]acetate.

The title compound, C₁₈H₁₆N₂O₃S, was synthesized by reaction of 2-mercapto-3- phenylquinazolin-4(3H)-one with ethyl chloroacetate. The quinazoline ring forms a dihedral angle of 86.83 (5)° with the phenyl ring. The terminal methyl group is disordered by a rotation of about 60° in a 0.531 (13): 0.469 (13) ratio. In the crystal, C--H…O hydrogen-bonding interactions result in the formation of columns running in the [010] direction. Two parallel columns further interact by C--H…O hydrogen bonds. The most important contributions to the surface contacts are from H…H (48.4%), C…H/H…C (21.5%) and O…H/H…O (18.7%) interactions, as concluded from a Hirshfeld analysis. [ABSTRACT FROM AUTHOR]