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Advances in the repair of segmental nerve injuries and trends in reconstruction.

Authors :
Pan, Deng
Mackinnon, Susan E.
Wood, Matthew D.
Source :
Muscle & Nerve; Jun2020, Vol. 61 Issue 6, p726-739, 14p
Publication Year :
2020

Abstract

Despite advances in surgery, the reconstruction of segmental nerve injuries continues to pose challenges. In this review, current neurobiology regarding regeneration across a nerve defect is discussed in detail. Recent findings include the complex roles of nonneuronal cells in nerve defect regeneration, such as the role of the innate immune system in angiogenesis and how Schwann cells migrate within the defect. Clinically, the repair of nerve defects is still best served by using nerve autografts with the exception of small, noncritical sensory nerve defects, which can be repaired using autograft alternatives, such as processed or acellular nerve allografts. Given current clinical limits for when alternatives can be used, advanced solutions to repair nerve defects demonstrated in animals are highlighted. These highlights include alternatives designed with novel topology and materials, delivery of drugs specifically known to accelerate axon growth, and greater attention to the role of the immune system. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0148639X
Volume :
61
Issue :
6
Database :
Complementary Index
Journal :
Muscle & Nerve
Publication Type :
Academic Journal
Accession number :
143217138
Full Text :
https://doi.org/10.1002/mus.26797