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Differences in metabolic profiles between bicuspid and tricuspid aortic stenosis in the setting of transcatheter aortic valve replacement.
- Source :
- BMC Cardiovascular Disorders; 5/18/2020, Vol. 20 Issue 1, p1-10, 10p, 2 Diagrams, 1 Chart, 4 Graphs
- Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>To explore why bicuspid aortic stenosis has certain clinical differences from the tricuspid morphology, we evaluated the metabolomics profile involved in bicuspid aortic valve (BAV) aortic stenosis prior to and after transcatheter aortic valve replacement (TAVR) in comparison with tricuspid aortic valve (TAV).<bold>Methods: </bold>In this TAVR cohort with prospectively collected data, blood samples were obtained before TAVR valve deployment and at the 7th day after TAVR, which were then sent for liquid and gas chromatography-mass spectrometry detection. Besides comparisons between BAV and TAV, BAV patients were also divided in subgroups according to baseline hemodynamics (i.e. maximal transaortic velocity, Vmax) and post-procedural reverse left ventricular (LV) remodeling (i.e. the change in LV mass index from baseline, ∆LVMI) for further analysis. Metabolic differences between groups were identified by integrating univariate test, multivariate analysis and weighted correlation network analysis algorithm.<bold>Results: </bold>A total of 57 patients were enrolled including 33 BAV patients. The BAV group showed lower arginine and proline metabolism both before and post TAVR than TAV represented by decreased expression of L-Glutamine. In BAV subgroup analysis, patients with baseline Vmax > 5 m/s (n = 11) or the 4th quartile of change in ∆LVMI at one-year follow-up (i.e. poorly-recovered LV, n = 8) showed elevated arachidonic acid metabolism compared with Vmax < 4.5 m/s (n = 12) or the 1st quartile of ∆LVMI (i.e. well-recovered LV, n = 8) respectively.<bold>Conclusions: </bold>Difference in arginine and proline metabolism was identified between BAV and TAV in TAVR recipients. Elevated arachidonic acid metabolism may reflect more severe baseline hemodynamics and worse LV reserve remodeling after TAVR in BAV. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEART valve prosthesis implantation
AORTIC stenosis
BICUSPIDS
LIQUID chromatography-mass spectrometry
MITRAL valve
AORTIC valve surgery
AORTIC valve abnormalities
HEART valve diseases
BIOCHEMISTRY
ENERGY metabolism
LEFT heart ventricle
RESEARCH
VENTRICULAR remodeling
CONVALESCENCE
RESEARCH methodology
ARGININE
EVALUATION research
MEDICAL cooperation
TREATMENT effectiveness
COMPARATIVE studies
PROSTHETIC heart valves
PROLINE
RESEARCH funding
HEMODYNAMICS
ARACHIDONIC acid
HEART physiology
AORTIC valve
LONGITUDINAL method
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 14712261
- Volume :
- 20
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Cardiovascular Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 143296773
- Full Text :
- https://doi.org/10.1186/s12872-020-01491-4