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Cobalt-catalyzed 2-(1-methylhydrazinyl)pyridine-assisted cyclization of thiophene-2-carbohydrazides with maleimides: efficient synthesis of thiophene-fused pyridones.
- Source :
- Chemical Communications; 5/21/2020, Vol. 56 Issue 41, p5524-5527, 4p
- Publication Year :
- 2020
-
Abstract
- A cobalt-catalyzed direct C–H/N–H functionalization of thiophene-2-carbohydrazides with maleimides by utilizing 2-(1-methylhydrazinyl)pyridine (MHP) as an easily removable bidentate directing group has been developed. This formal [4+2] cycloaddition has been achieved for the first time, and it provides an alternative and versatile approach to construct thiophene-fused pyridones using an inexpensive cobalt catalyst. The C–H/N–H activation cascade protocol showed a high efficiency and a broad substrate scope, and the products were obtained in good to excellent yields. [ABSTRACT FROM AUTHOR]
- Subjects :
- COBALT catalysts
IMIDAZOPYRIDINES
RING formation (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 56
- Issue :
- 41
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 143361885
- Full Text :
- https://doi.org/10.1039/d0cc01582b