Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation.

2 Molecular and clinical portrait of H3 wild-type DMG patients. a Clinicopathological and molecular annotations are provided as bars for 19 histone H3 wild-type DMG patients. Samples are arranged in columns with genes labeled along rows. b Distribution of normalized EZHIP gene expression level, in H3-K27M (green, n = 20) and H3 wild-type (grey, n = 11) DMG patients. We propose that these EZHIP/H3-WT tumors need to be considered similar to canonical DIPG/DMG, thus extending the spectrum of DMG with PRC2 inhibition beyond H3-K27M mutation. [Extracted from the article]