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Recovery of brain DHA-containing phosphatidylserine and ethanolamine plasmalogen after dietary DHA-enriched phosphatidylcholine and phosphatidylserine in SAMP8 mice fed with high-fat diet.
- Source :
- Lipids in Health & Disease; 5/25/2020, Vol. 19 Issue 1, p1-12, 12p, 8 Charts, 2 Graphs
- Publication Year :
- 2020
-
Abstract
- Background: Glycerophospholipids were the main components of cerebral cortex lipids, and there was a close association between lipid homeostasis and human health. It has been reported that dietary DHA-enriched phosphatidylcholine (DHA-PC) and phosphatidylserine (DHA-PS) could improve brain function. However, it was unclear that whether supplementation of DHA-PC and DHA-PS could change lipid profiles in the brain of dementia animals. Methods: SAMP8 mice was fed with different diet patterns for 2 months, including high-fat diet and low-fat diet. After intervention with DHA-PC and DHA-PS for another 2 months, the lipid profile in cerebral cortex was determined by lipidomics in dementia mice. Results: High-fat diet could significantly decrease the levels of DHA-containing PS/pPE, DPA-containing PS, and AA-containing PE, which might exhibit the potential of lipid biomarkers for the prevention and diagnosis of AD. Notably, DHA-PC and DHA-PS remarkably recovered the lipid homeostasis in dementia mice. These might provide a potential novel therapy strategy and direction of dietary intervention for patients with cognitive decline. Conclusions: DHA-PC and DHA-PS could recover the content of brain DHA-containing PS and pPE in SAMP8 mice fed with high-fat diet. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIGH-fat diet
CEREBRAL cortex
LOW-fat diet
LECITHIN
MICE
GLYCEROPHOSPHOLIPIDS
Subjects
Details
- Language :
- English
- ISSN :
- 1476511X
- Volume :
- 19
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Lipids in Health & Disease
- Publication Type :
- Academic Journal
- Accession number :
- 143395974
- Full Text :
- https://doi.org/10.1186/s12944-020-01253-3