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MicroRNA-155 complementation on a chemically functionalized dual electrode surface for determining breast cancer.
- Source :
- 3 Biotech; 5/28/2020, Vol. 10 Issue 6, p1-8, 8p
- Publication Year :
- 2020
-
Abstract
- This study correlated and quantified the expression of microRNA-155 with breast cancer to determine breast cancer progression. The target microRNA-155 sequence was identified by complementation on a capture-probe sequence-immobilized interdigitated dual electrode surface. The sensitivity was found to be 1 fM, and the limit of detection fell between 1 and 10 fM. The specific sequence selectivity with single mismatches, triple mismatches, and noncomplementary bases failed to complement the capture-probe sequence. The obtained results demonstrate the selective determination of the microRNA-155 sequence and can help to diagnose breast cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- BREAST cancer
ELECTRODES
CANCER invasiveness
DETECTION limit
Subjects
Details
- Language :
- English
- ISSN :
- 2190572X
- Volume :
- 10
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- 3 Biotech
- Publication Type :
- Academic Journal
- Accession number :
- 143476592
- Full Text :
- https://doi.org/10.1007/s13205-020-02261-x