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MicroRNA-155 complementation on a chemically functionalized dual electrode surface for determining breast cancer.

Authors :
Gopinath, Subash C. B.
Perumal, Veeradasan
Xuan, Shijin
Source :
3 Biotech; 5/28/2020, Vol. 10 Issue 6, p1-8, 8p
Publication Year :
2020

Abstract

This study correlated and quantified the expression of microRNA-155 with breast cancer to determine breast cancer progression. The target microRNA-155 sequence was identified by complementation on a capture-probe sequence-immobilized interdigitated dual electrode surface. The sensitivity was found to be 1 fM, and the limit of detection fell between 1 and 10 fM. The specific sequence selectivity with single mismatches, triple mismatches, and noncomplementary bases failed to complement the capture-probe sequence. The obtained results demonstrate the selective determination of the microRNA-155 sequence and can help to diagnose breast cancer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2190572X
Volume :
10
Issue :
6
Database :
Complementary Index
Journal :
3 Biotech
Publication Type :
Academic Journal
Accession number :
143476592
Full Text :
https://doi.org/10.1007/s13205-020-02261-x