N‐terminal peptide deletion influences immunological and structural features of Blo t 5.

Keywords: allergens and epitopes; IgE; immunotherapy vaccines and mechanisms EN allergens and epitopes IgE immunotherapy vaccines and mechanisms 1503 1507 5 06/01/20 20200601 NES 200601 Studies demonstrated that among the identified I B tropicalis i allergens, Blo t 5 is a major allergen,[[1], [3]] which makes the protein a target for diagnosis and allergen-specific immunotherapy (AIT). Cross-inhibition results showed that rBlo t 5 SB short sb cannot always inhibit the rDer p 5-specific IgE, but rDer p 5 possesses a moderate inhibitory capacity on rBlo t 5 SB short sb -specific IgE binding (Figure S4F). Blomia tropicalis Blo t 5 and Blo t 21 recombinant allergens might confer higher specificity to serodiagnostic assays than whole mite extract. [Extracted from the article]