Immune escape by loss of heterozygosis of HLA genes facilitated the transmission of diffuse large B cell lymphoma from mother to offspring.

Keywords: diffuse large B-cell lymphoma; maternal-to-fetus; transmission; HLA genes; loss of heterozygosis EN diffuse large B-cell lymphoma maternal-to-fetus transmission HLA genes loss of heterozygosis e234 e237 4 06/18/20 20200615 NES 200615 Peripheral blood cells can migrate reciprocally between the mother and fetus, resulting in microchimerism.[1] In contrast, the fetuses are protected from cancer metastasis from the mother structurally by the placental syncytiotrophoblast layer, or by immunological defenses through fetal T lymphocytes. Both maternal and fetal lymphoma cells had lost non-inherited maternal HLA alleles, suggesting the mechanism of immune escape. [Extracted from the article]