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Three-Component Synthesis of 2-Alkylthiobenzoazoles in Aqueous Media.
- Source :
- Synthesis; 2020, Vol. 52 Issue 13, p1927-1933, 7p
- Publication Year :
- 2020
-
Abstract
- A highly efficient three-component protocol for the synthesis of the 2-alkylthiobenzoazoles is described. Tetramethylthiuram disulfide (TMTD) cyclized with o -aminothiophenols, generating the intermediate 2-mercaptobenzothiazoles, and the successive C–S coupling with halogenated alkanes afforded a series of 2-alkyl-substituted thiobenzothiazoles smoothly in a one-pot process. This procedure could also be utilized for the preparation of 2-alkyl-substituted thiobenzoxazoles and 2-alkyl-substituted thiobenzimidazoles. Inexpensive and easily available starting materials, metal catalyst-free, broad substrate scope, and water as solvent are the features of this protocol. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 52
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 143803573
- Full Text :
- https://doi.org/10.1055/s-0039-1690854