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T-cell responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients.
- Source :
- Scientific Reports; 6/22/2020, Vol. 10 Issue 1, p1-9, 9p
- Publication Year :
- 2020
-
Abstract
- Little is known about cell-mediated immune responses to natural influenza infection in solid organ transplant (SOT) patients. The aim of our study was to evaluate the CD4<superscript>+</superscript> and CD8<superscript>+</superscript> responses to influenza A and B infection in a cohort of SOT patients. We collected peripheral blood mononuclear cells at influenza diagnosis and four weeks later from 31 SOT patients during the 2017–2018 influenza season. Infection-elicited influenza-specific CD4<superscript>+</superscript> and CD8<superscript>+</superscript> T-cell responses were measured using flow cytometry and intracellular cytokine staining and compared to responses following influenza vaccine in SOT patients. Natural infection was associated with a significant increase in CD4<superscript>+</superscript> T-cell responses. For example, polyfunctional cells increased from 21 to 782 and from 193 to 1436 cells per 10<superscript>6</superscript> CD4<superscript>+</superscript> T-cells among influenza A/H3N2 and B-infected patients (p = 0.006 and 0.004 respectively). Moreover, infection-elicited CD4<superscript>+</superscript> responses were superior than vaccine-elicited responses for influenza A/H1N1 (931 vs 1; p = 0.026), A/H3N2 (647 vs 1; p = 0.041) and B (619 vs 1; p = 0.004). Natural influenza infection triggers a significant increase in CD4<superscript>+</superscript> T-cell responses in SOT patients. Infection elicits significantly stronger CD4<superscript>+</superscript> responses compared to the influenza vaccine and thereby likely elicits better protection against reinfection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 143892256
- Full Text :
- https://doi.org/10.1038/s41598-020-67172-6