Back to Search
Start Over
Cooperative Silver‐ and Base‐Catalyzed Diastereoselective Cycloaddition of Nitrones with Methylene Isocyanides: Access to 2‐Imidazolinones.
- Source :
- European Journal of Organic Chemistry; 6/23/2020, Vol. 2020 Issue 23, p3475-3479, 5p
- Publication Year :
- 2020
-
Abstract
- A protocol involving cooperative silver‐ and base‐catalyzed diastereoselective cycloaddition of nitrones with isocyanides is described, providing access to a wide range of 2‐imidazolinone derivatives with various functional groups as single diastereomers. Varying the base and temperature of the reaction allowed selective access to both diastereomers of the product. A plausible reaction mechanism is proposed and supported by DFT calculations. [ABSTRACT FROM AUTHOR]
- Subjects :
- NITRONES
ISOCYANIDES
RING formation (Chemistry)
FUNCTIONAL groups
DIASTEREOISOMERS
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2020
- Issue :
- 23
- Database :
- Complementary Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 144200725
- Full Text :
- https://doi.org/10.1002/ejoc.202000437