Association between plasma and urinary orosomucoid and chronic kidney disease in adults with sickle cell disease.

Keywords: sickle cell disease; orosomucoid; chronic kidney disease; urinary biomarker EN sickle cell disease orosomucoid chronic kidney disease urinary biomarker e45 e48 4 07/01/20 20200701 NES 200701 Chronic kidney disease (CKD) strongly contributes to morbidity and mortality in ageing sickle cell disease (SCD) patients.[1] Biomarkers for early stage CKD, such as proteinuria, microalbuminuria and reduced glomerular filtration rate (GFR), are difficult to detect in SCD patients because of a urine concentration defect. HbSS patients had higher prevalence and more severe kidney disease than HbSC (27-3% of HbSS patients were in stages 3 and 4). This observation supports the previous observation that HbSS patients have higher prevalence of proteinuria and albuminuria than HbSC.[4] 1 TableBasic characteristics and renal function in HbSS and HbSC patients. [Extracted from the article]