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The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A3 Receptor Agonist, in a Rat Model of Colitis.

The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A3 Receptor Agonist, in a Rat Model of Colitis.

Authors :
Antonioli, Luca
Lucarini, Elena
Lambertucci, Catia
Fornai, Matteo
Pellegrini, Carolina
Benvenuti, Laura
Di Cesare Mannelli, Lorenzo
Spinaci, Andrea
Marucci, Gabriella
Blandizzi, Corrado
Ghelardini, Carla
Volpini, Rosaria
Dal Ben, Diego
Source :
Cells (2073-4409); Jun2020, Vol. 9 Issue 6, p1509-1509, 1p
Publication Year :
2020

Abstract

The pharmacological activation of A<subscript>3</subscript> receptors has shown potential usefulness in the management of bowel inflammation. However, the role of these receptors in the control of visceral hypersensitivity in the presence of intestinal inflammation has not been investigated. The effects of AR170, a potent and selective A<subscript>3</subscript> receptor agonist, and dexamethasone (DEX) were tested in rats with 2,4-dinitrobenzene sulfonic acid (DNBS)-induced colitis to assess their tissue inflammatory parameters. The animals received AR170, DEX, or a vehicle intraperitoneally for 6 days, starting 1 day before the induction of colitis. Visceral pain was assessed by recording the abdominal responses to colorectal distension in animals with colitis. Colitis was associated with a decrease in body weight and an increase in spleen weight. The macroscopic damage score and tissue tumor necrosis factor (TNF), interleukin 1β (IL-1β), and myeloperoxidase (MPO) levels were also enhanced. AR170, but not DEX, improved body weight. Both drugs counteracted the increase in spleen weight, ameliorated macroscopic colonic damage, and decreased TNF, IL-1β, and MPO tissue levels. The enhanced visceromotor response (VMR) in rats with colitis was decreased via AR170 administration. In rats with colitis, AR170 counteracted colonic inflammatory cell infiltration and decreased pro-inflammatory cytokine levels, thereby relieving visceral hypersensitivity. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734409
Volume :
9
Issue :
6
Database :
Complementary Index
Journal :
Cells (2073-4409)
Publication Type :
Academic Journal
Accession number :
144482250
Full Text :
https://doi.org/10.3390/cells9061509