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Bioactive constituents from Salacia cochinchinensis.
- Source :
- Journal of Asian Natural Products Research; Aug2020, Vol. 22 Issue 8, p738-745, 8p
- Publication Year :
- 2020
-
Abstract
- Two new isopimarane diterpenoids, named 1α-hydroxy-7-oxoisopimara-8, 15-diene (1), 11β-hydroxy-7-oxoisopimara-8(14), 15-diene (2), together with six known compounds (3-8), were isolated from the medicinal plant Salacia cochinchinensis. All isolates were assayed for their cytotoxicity and α-glucosidase inhibitory activity. Results suggested compounds 1, 3 possessed significant cytotoxic activity against HepG2, HL60, and Hela cell lines with IC<subscript>50</subscript> values ranging from 0.23 to 0.35 μM, and compounds 7, 8 exhibited noticeable α-glucosidase inhibitory ability with IC<subscript>50</subscript> values of 0.25 and 0.31 μM, respectively. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 22
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 144501156
- Full Text :
- https://doi.org/10.1080/10286020.2019.1618279