Long‐term follow‐up of neonatal intracranial haemorrhage in children with severe haemophilia.

Keywords: intracranial haemorrhage; neonatal haematology; children; haemophilia; \sequelae EN intracranial haemorrhage neonatal haematology children haemophilia \sequelae e101 e104 4 07/20/20 20200715 NES 200715 Intracranial haemorrhage (ICH) in neonates with severe haemophilia is a potentially life-threatening complication and has been reported to occur in about 2-4% of boys with severe haemophilia; around 44-60 times higher than that expected in a non-haemophilia population.1,2 ICH requires intensive replacement therapy with factor concentrates, which has been identified as a risk factor for inhibitor development in patients with haemophilia A (HA).3 Death and neurological sequelae (motor function problems, seizures and developmental delay) are the most feared complications and have been reported to affect 50-60% of children with ICH.4 The aim of this paper was to study the incidence and symptoms of ICH in neonates with severe haemophilia and the impact of early diagnosis and treatment of ICH on long-term outcomes. The case report form registered patients' type of haemophilia, mode of delivery, ICH, and in cases of ICH, neurological signs and symptoms at presentation, treatment and sequelae. To be able to compare neonatal ICH incidences to ICH incidences later in life, the 450 neonatal months were added up to 34-52 patient years, resulting in an incidence of 0-26 ICH/patient year. The neonate might not be diagnosed as having haemophilia if there is no family history of haemophilia, symptoms like lethargy and vomiting are non-specific and not all cases of ICH are detected. [Extracted from the article]