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Pharmacological potential of tocopherol and doxycycline against traumatic brain injury-induced cognitive/motor impairment in rats.
- Source :
- Brain Injury; 2020, Vol. 34 Issue 8, p1039-1050, 12p
- Publication Year :
- 2020
-
Abstract
- The primary objective of this study was to explore the pharmacological potential of tocopherol and doxycycline against traumatic brain injury-induced cognitive/motor impairment in rats. Weight drop model of traumatic brain injury. After TBI, the animals were treated with doxycycline (50 and 100 mg/kg; p.o), tocopherol (5 and 10 mg/kg; p.o) alone and in combination as doxycycline and tocopherol (50 and 10 mg/kg; p.o) from 1st day to 28th day. The behavioral parameters were performed on a weekly basis from 1st day to 28th day. On 29th day, animals were sacrificed and striatum and cortex were homogenized for the estimation of biochemical (LPO, nitrite, and GSH), neuroinflammatory (IL-6, IL-1β, and TNF-α), and neurotransmitters (dopamine, norepinephrine, serotonin, GABA, and glutamate) analysis. Induction of TBI had significantly reduced locomotor activity, recognition memory, increased neuroinflammatory markers, and imbalance neurotransmitter levels. The treatment with doxycycline and tocopherol alone and in combination significantly attenuated locomotor activity, memory recognition, reduced neuroinflammation, preserved oxidative balance, and restored the level of neurotransmitters. The neuroprotective effect of doxycycline and tocopherol might be due to its anti-inflammatory and free radical scavenging mechanisms. TBI: Traumatic brain injury; Doxy: Doxycycline; Toco: Tocopherol; LPO: Lipid peroxidation; MDA: Malondialdehyde; TNF-α: Tumor necrosis factor-alpha; IL-1b: Interleukin-1 beta; GSH: Glutathione; GABA: gamma-Aminobutyric acid. [ABSTRACT FROM AUTHOR]
- Subjects :
- DOPAMINE analysis
ANIMAL experimentation
BASAL ganglia
BEHAVIOR modification
BIOLOGICAL models
BRAIN injuries
CEREBRAL cortex
COMBINATION drug therapy
COGNITION disorders
GABA
INTERLEUKINS
MEMORY
MOVEMENT disorders
NEUROTRANSMITTERS
NITRITES
NORADRENALINE
RATS
RECOGNITION (Psychology)
SEROTONIN
VITAMIN E
OXIDATIVE stress
DOXYCYCLINE
Subjects
Details
- Language :
- English
- ISSN :
- 02699052
- Volume :
- 34
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Brain Injury
- Publication Type :
- Academic Journal
- Accession number :
- 144655142
- Full Text :
- https://doi.org/10.1080/02699052.2020.1772508