Back to Search Start Over

Effects of NAD+ in Caenorhabditis elegans Models of Neuronal Damage.

Authors :
Lee, Yuri
Jeong, Hyeseon
Park, Kyung Hwan
Kim, Kyung Won
Source :
Biomolecules (2218-273X); Jul2020, Vol. 10 Issue 7, p993, 1p
Publication Year :
2020

Abstract

Nicotinamide adenine dinucleotide (NAD<superscript>+</superscript>) is an essential cofactor that mediates numerous biological processes in all living cells. Multiple NAD<superscript>+</superscript> biosynthetic enzymes and NAD<superscript>+</superscript>-consuming enzymes are involved in neuroprotection and axon regeneration. The nematode Caenorhabditis elegans has served as a model to study the neuronal role of NAD<superscript>+</superscript> because many molecular components regulating NAD<superscript>+</superscript> are highly conserved. This review focuses on recent findings using C. elegans models of neuronal damage pertaining to the neuronal functions of NAD<superscript>+</superscript> and its precursors, including a neuroprotective role against excitotoxicity and axon degeneration as well as an inhibitory role in axon regeneration. The regulation of NAD<superscript>+</superscript> levels could be a promising therapeutic strategy to counter many neurodegenerative diseases, as well as neurotoxin-induced and traumatic neuronal damage. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2218273X
Volume :
10
Issue :
7
Database :
Complementary Index
Journal :
Biomolecules (2218-273X)
Publication Type :
Academic Journal
Accession number :
144771462
Full Text :
https://doi.org/10.3390/biom10070993