CCL2 mitigates cyclic AMP‐suppressed Th2 immune response in human dendritic cells.

CCL2 mitigates cyclic AMP-suppressed Th2 immune response in human dendritic cells Keywords: allergic rhinitis; cAMP; CCL2; dendritic cells; Gnas CD11c mice EN allergic rhinitis cAMP CCL2 dendritic cells Gnas CD11c mice 1 4 4 07/29/20 20200801 NES 200801 Allergic rhinitis (AR) is a Th2-type chronic inflammatory disease of the nasal mucosa, characterized by symptoms including rhinorrhea, obstruction, and sneezing. However, CCL7 mRNA in AR MDDCs was not different from that in control MDDCs (Figure S4), suggesting that decreased cAMP levels in AR DCs induce the Th2 immune response through upregulation of CCL2. [Extracted from the article]