Back to Search
Start Over
Pneumocystis carinii in children with severe pneumonia at Mulago Hospital, Uganda.
- Source :
- Annals of Tropical Paediatrics; Sep2004, Vol. 24 Issue 3, p227-235, 9p
- Publication Year :
- 2004
-
Abstract
- The prevalence of Pneumocystis carinii pneumonia (PCP), its clinical and radiological features and the outcome in 121 children aged 2–60 months presenting with severe pneumonia over a 2-month period at Mulago Hospital, Kampala are described. Children presenting with severe pneumonia had sputum induction using 3% hypertonic saline. The sputum was stained using PCP monoclonal antibodies and viewed with fluorescent micros- copy. Twenty children with confirmed PCP were compared with 101 without PCP. The prevalence of PCP was 16.5%, and 12 (60%) were <6 months of age. Eighteen (42%) of 43 children infected with HIV had PCP and two of 78 not infected with HIV. The outcome in children with PCP was poor with a case fatality rate of 40% compared with 20% in those without HIV. Radiological findings were non-specific. Clinical features associated with PCP included: HIV-positive infants with a small head circumference, AIDS, a clear chest on auscultation and elevated LDH levels. PCP occurs in one in six children <5 years with severe pneumonia in Mulago Hospital. In developing countries where investigations for PCP are not routinely available, infants suspected of PCP should be treated as an emergency. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02724936
- Volume :
- 24
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Annals of Tropical Paediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 14509762
- Full Text :
- https://doi.org/10.1179/027249304225019046