Prognostic value of morphology and hormone receptor status in breast cancer-a population-based study.

We analysed the S-year relative survival among 4473 breast cancer cases diagnosed in 1990- 1992 from cancer registries in Estonia, France, Italy, Spain, the Netherlands and the UK. Among eight categories based on ICD-O codes (infiltrating ductal carcinoma, lobular plus mixed carcinoma, comedocarcinoma, `special types', medullary carcinoma, not otherwise specified (NOS) carcinoma, other carcinoma and cancer without microscopic confirmation), the S-year relative survival ranged from 66% (95% CI 61 -71) for NOS carcinoma to 95% (95% CI 90-100) for special types (tubular, apocrine, cribriforrn, papillary, mucinous and signet ring cell); 27% (95% CI 18-36) for cases without microscopic confirmation. Differences in 5-year relative survival by tumor morphology and hormone receptor status were modelled using a multiple regression approach based on generalised linear models. Morphology and hormone receptor status were confirmed as significant survival predictors in this population-based study, even after adjusting for age and stage at diagnosis. [ABSTRACT FROM AUTHOR]