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LYMPHOCYTE ACTIVATION II. DISCRIMINATING STIMULATION OF LYMPHOCYTE SUBPOPULATIONS BY PHYTOMITOGENS AND HETEROLOGOUS ANTILYMPHOCYTE SERA.
- Source :
- Clinical & Experimental Immunology; Mar1972, Vol. 10 Issue 3, p525-536, 12p
- Publication Year :
- 1972
-
Abstract
- The mitogenic selectivity of four phytomitogens, phytohaemagglutinin (PHA), concanavalin (ConA), lentil mitogen (LM) and pokeweed mitogen .(PWM), and a series of heterologous antilymphocyte sera (ALS) for mouse T and B lymphocytes has been investigated using thymidine uptake as a measure of proliferative activity. The results show that PHA, ConA and LM stimulate T but not B cells whereas PWM activates both T and B cells. Of six mitogenically active ALS, five were T cell specific and one B cell specific. Cortisone resistant (T) cells within the thymus showed a much greater response to all mitogens than unselected thymocytes. However, ConA and LM activated a considerable response in the latter population. Selective activation of T and B cells by aspecific means may be useful both as a clinical tool and as an approach to gaining an understanding of antigen induction of immune responses. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHOCYTES
MITOGENS
T cells
B cells
IMMUNE response
ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 10
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14545514