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Analysis of lymphocyte T(CD4+) cells expression on severe early childhood caries and free caries.
- Source :
- Infectious Disease Reports; 2020 Supplement, Vol. 12, p113-116, 4p
- Publication Year :
- 2020
-
Abstract
- Early childhood caries (ECC) is still one of the many diseases found in children throughout the world. Cariogenic bacteria are a significant risk factor for ECC associated with early colonization and high levels of cariogenic microbes (Streptococcus mutans, S. mutans). Lymphocyte T (CD4+) cells known as helper T cells, are effector cells for mediated host immunity. Naive T cells (CD4+) must be activated to initiate effector function. This activation occurs through interaction with professional antigen- presenting cells (pro-APC), especially dendritic cells that lead to intracellular pathways that regulate T cell receptor (TCR) more specifically against antigen in T cells. Lymphocyte cells from samples were collected from severe early childhood caries (S-ECC) and Free caries aged 5 to 6 years. The subjects were instructed to gargle 10 mL of sterile NaCl 1.5% solution for 30 seconds, and expectorate it into a sterile glass then analyzing T lymphocyte cell (CD4+) expression using flow cytometry. Lymphocyte T (CD4+) cell expression at SECC (6.2525±64482) while in free caries (8.4138±1.10397) with P-value (P=0. 000). Conclusion of lymphocyte T (CD4+) cells expression at S-ECC is lower than that occurring in free caries. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20367449
- Volume :
- 12
- Database :
- Complementary Index
- Journal :
- Infectious Disease Reports
- Publication Type :
- Academic Journal
- Accession number :
- 145483301
- Full Text :
- https://doi.org/10.4081/idr.2020.8760