Non-invasive Diagnostic Strategy in ACTH-dependent Cushing's Syndrome.

<bold>Context: </bold>Inferior petrosal sinus sampling (IPSS) is used to diagnose Cushing's disease (CD) when dexamethasone-suppression and CRH tests, and pituitary magnetic resonance imaging (MRI), are negative or give discordant results. However, IPSS is an invasive procedure and its availability is limited.<bold>Objective: </bold>To test a noninvasive diagnostic strategy associated with 100% positive predictive value (PPV) for CD.<bold>Design: </bold>Retrospective study.<bold>Setting: </bold>Two university hospitals.<bold>Patients: </bold>A total of 167 patients with CD and 27 patients with ectopic ACTH-syndrome investigated between 2001 and 2016.<bold>Main Outcome Measure(s): </bold>Performance of a strategy involving the CRH and desmopressin tests with pituitary MRI followed by thin-slice whole-body computed tomography (CT) scan in patients with inconclusive results.<bold>Results: </bold>Using thresholds of a cortisol increase > 17% with an ACTH increase > 37% during the CRH test and a cortisol increase > 18% with an ACTH increase > 33% during the desmopressin test, the combination of both tests gave 73% sensitivity and 98% PPV of CD. The sensitivity and PPV for pituitary MRI were 71% and 99%, respectively. CT scan identified 67% EAS at presentation with no false-positives. The PPV for CD was 100% in patients with positive responses to both tests, with negative pituitary MRI and CT scan. The Negative Predictive Value was 100% in patients with negative responses to both tests, with negative pituitary MRI and positive CT scan. Using this strategy, IPPS could have been avoided in 47% of patients in whom it is currently recommended.<bold>Conclusions: </bold>In conjunction with expert radiologic interpretation, the non-invasive algorithm studied significantly reduces the need for IPSS in the investigation of ACTH-dependent Cushing's syndrome. [ABSTRACT FROM AUTHOR]