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Evaluation of HIV-specific T-cell responses in HIV-infected older patients with controlled viremia on long-term antiretroviral therapy.
- Source :
- PLoS ONE; 9/17/2020, Vol. 15 Issue 9, p1-18, 18p
- Publication Year :
- 2020
-
Abstract
- HIV-infected older individuals may have a diminished immune response because of exhaustion/immune aging of T-cells. Therefore, we have investigated HIV-specific CD4 and CD8 T-cell responses in 100 HIV-infected patients (HIV<superscript>+</superscript>) who have aged on long-term antiretroviral therapy (ART) and achieved controlled viremia (mostly undetectable viral load; 92 patients with <20 to <40 HIV RNA copies/mL and 8 <60 to <100) and improved CD4 T-cell counts. We show that the median frequencies of HIV-specific CD4<superscript>+</superscript> and CD8<superscript>+</superscript> IFN-γ T-cells were higher in HIV<superscript>+</superscript> than uninfected individuals (HIV<superscript>-</superscript>), including increasing levels of IFN-γproduced by CD4<superscript>+</superscript> T-cells and decreasing levels by CD8<superscript>+</superscript> T-cells with increasing CD4 T-cell counts in HIV<superscript>+</superscript>. No correlation was found between T-cell responses and varying levels of undetectable viremia. HIV-specific TNF-α made by CD8<superscript>+</superscript> T-cells was higher in HIV<superscript>+</superscript> than HIV<superscript>-</superscript>, including decreasing levels with increasing CD4 T-cell counts in HIV<superscript>+</superscript>. Furthermore, the CD8<superscript>+</superscript> T-cell mediators, CD107a and Granzyme-B, were higher in HIV<superscript>+</superscript> than HIV<superscript>-</superscript>, and decreased with increasing CD4 T-cell counts in HIV<superscript>+</superscript>. Remarkably, HIV-specific CD8 T-cells produced decreasing levels of IFN-γwith increasing age of HIV<superscript>+</superscript>, including decreased levels of CD107a and Granzyme-B in older HIV<superscript>+</superscript>. However, HIV-specific CD8<superscript>+</superscript> T-cells produced increasing levels of TNF-α with increasing age of the HIV<superscript>+</superscript>, suggesting continued inflammation. In conclusion, HIV<superscript>+</superscript> with controlled viremia on long-term ART and with higher CD4 T-cell counts showed reduced HIV-specific CD8 T-cell responses as compared to those with lower CD4 T-cell counts, and older HIV<superscript>+</superscript> exhibited decreasing levels of CD8 T-cell responses with increasing age. [ABSTRACT FROM AUTHOR]
- Subjects :
- OLDER patients
ANTIRETROVIRAL agents
VIRAL load
CD4 lymphocyte count
VIREMIA
T cells
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 145953656
- Full Text :
- https://doi.org/10.1371/journal.pone.0236320