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Bioelectronic control of chloride ions and concentration with Ag/AgCl contacts.
- Source :
- APL Materials; Sep2020, Vol. 8 Issue 9, p1-7, 7p
- Publication Year :
- 2020
-
Abstract
- Translation between ionic currents and measurable electronic signals is essential for the integration of natural systems and artificial bioelectronic devices. Chloride ions (Cl<superscript>−</superscript>) play a pivotal role in bioelectricity, and they are involved in several brain pathologies, including epilepsy and disorders of the autistic spectra, as well as cancer and birth defects. As such, controlling [Cl<superscript>−</superscript>] in solution can actively influence biochemical processes and can be used in bioelectronic therapies. Here, we demonstrate a bioelectronic device that uses Ag/AgCl contacts to control [Cl<superscript>−</superscript>] in solution by electronic means. We do so by exploiting the potential dependence of the reversible reaction, Ag + Cl<superscript>−</superscript> ↔ AgCl + e<superscript>−</superscript>, at the contact/solution interface, which is at the basis of the well-known Ag/AgCl reference electrode. In short, a negative potential on the Ag/AgCl contact transfers Cl<superscript>−</superscript> from the contact to the solution with increasing [Cl<superscript>−</superscript>] and vice versa. With this strategy, we demonstrate precise spatiotemporal control of [Cl<superscript>−</superscript>] in solution that can be used to affect physiological processes that are dependent on [Cl<superscript>−</superscript>]. As proof-of-concept, we use [Cl<superscript>−</superscript>] control to influence the membrane voltage on human pluripotent stem cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2166532X
- Volume :
- 8
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- APL Materials
- Publication Type :
- Academic Journal
- Accession number :
- 146194962
- Full Text :
- https://doi.org/10.1063/5.0013867