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Improved Time in Range Over 1 Year Is Associated With Reduced Albuminuria in Individuals With Sensor-Augmented Insulin Pump-Treated Type 1 Diabetes.
- Source :
- Diabetes Care; Nov2020, Vol. 43 Issue 11, p2882-2885, 4p
- Publication Year :
- 2020
-
Abstract
- <bold>Objective: </bold>To investigate the association between treatment-induced change in continuous glucose monitoring (CGM) time in range (TIR) and albuminuria in persons with type 1 diabetes (T1D) treated with sensor-augmented insulin pumps (SAP).<bold>Research Design and Methods: </bold>Twenty-six out of 55 participants with albuminuria and multiple daily injection therapy (25% females; median 51 [interquartile range 46-63] years of age; glycated hemoglobin A1c (HbA1c) 75 [68-88] mmol/mol [9.0% (8.4-10.4%)]; and urinary albumin-to-creatinine ratio (UACR) 89 [37-250] mg/g) were in a randomized controlled trial assigned to SAP therapy for 1 year. Anthropometrics, CGM data, and blood and urine samples were collected every 3 months.<bold>Results: </bold>Mean change (95% CI) in percentage of TIR (%TIR) was 13.2% (6.2; 20.2), in HbA1c was -14.4 (-17.4; -10.5) mmol/mol (-1.3% [-1.6; -1.0]), and in UACR was -15% (-38; 17) (all P < 0.05). UACR decreased by 19% (10; 28) per 10% increase in %TIR (P = 0.04), 18% (1; 30) per 10 mmol/mol decrease in HbA1c (P = 0.07), and 31% per 10-mmHg decrease in mean arterial pressure (P < 0.001).<bold>Conclusions: </bold>In this longitudinal study, treatment-induced increase in %TIR was significantly associated with decrease in albuminuria in T1D. [ABSTRACT FROM AUTHOR]
- Subjects :
- TYPE 1 diabetes
ALBUMINURIA
GLYCOSYLATED hemoglobin
INSULIN pumps
INSULIN
BLOOD sugar analysis
RESEARCH
TIME
BLOOD sugar monitoring
RESEARCH methodology
HYPOGLYCEMIC agents
MEDICAL cooperation
EVALUATION research
TREATMENT effectiveness
COMPARATIVE studies
CREATININE
LONGITUDINAL method
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 01495992
- Volume :
- 43
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Diabetes Care
- Publication Type :
- Academic Journal
- Accession number :
- 146526399
- Full Text :
- https://doi.org/10.2337/dc20-0909