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Assessing regulatory features of the current transcriptional network of Saccharomyces cerevisiae.
- Source :
- Scientific Reports; 10/20/2020, Vol. 10 Issue 1, p1-11, 11p
- Publication Year :
- 2020
-
Abstract
- The capacity of living cells to adapt to different environmental, sometimes adverse, conditions is achieved through differential gene expression, which in turn is controlled by a highly complex transcriptional network. We recovered the full network of transcriptional regulatory associations currently known for Saccharomyces cerevisiae, as gathered in the latest release of the YEASTRACT database. We assessed topological features of this network filtered by the kind of supporting evidence and of previously published networks. It appears that in-degree distribution, as well as motif enrichment evolve as the yeast transcriptional network is being completed. Overall, our analyses challenged some results previously published and confirmed others. These analyses further pointed towards the paucity of experimental evidence to support theories and, more generally, towards the partial knowledge of the complete network. [ABSTRACT FROM AUTHOR]
- Subjects :
- SACCHAROMYCES cerevisiae
GENE expression
DATABASES
BIOCHEMISTRY
BIOLOGICALS
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 146532588
- Full Text :
- https://doi.org/10.1038/s41598-020-74043-7