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Circulating intermediate monocytes and toll-like receptor 4 correlate with low-voltage zones in atrial fibrillation.
- Source :
- Heart & Vessels; Dec2020, Vol. 35 Issue 12, p1717-1726, 10p
- Publication Year :
- 2020
-
Abstract
- Inflammation has been suggested to play a key role in the pathogenesis of atrial fibrillation (AF). Our hypothesis was that this inflammation, mediated by intermediate monocytes and toll-like receptor 4 (TLR4), causes the formation and expansion of low-voltage zones (LVZs). Prior to ablation, the monocyte subsets of 78 AF patients and TLR4 expression of 66 AF patients were analyzed via a flow cytometric analysis. Based on the CD14/CD16 expression, the monocytes were divided into three subsets: classical, intermediate, and non-classical. At the beginning of the ablation session, voltage mapping was performed. LVZs were defined as all bipolar electrogram amplitudes of < 0.5 mV. Correlations between the flow cytometric analysis results and presence of LVZs, as well as the total area of the LVZ, were examined. Patients with LVZs clearly had a higher proportion of intermediate monocytes (10.0 ± 3.6% vs. 7.2 ± 2.7%, p < 0.001) than those without LVZs. TLR4 was much more frequently expressed in the intermediate monocytes than other two monocyte subsets (p < 0.001). Moreover, the TLR4 expression level in intermediate monocytes correlated positively with the total area of the LVZs (r = 0.267, p = 0.030), especially in patients with paroxysmal AF (r = 0.365, p = 0.015). The intermediate monocytes and TLR4 expression positively correlated with LVZs in AF patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- ATRIAL fibrillation
TOLL-like receptors
MONOCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 09108327
- Volume :
- 35
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Heart & Vessels
- Publication Type :
- Academic Journal
- Accession number :
- 146710796
- Full Text :
- https://doi.org/10.1007/s00380-020-01647-4