EFFECT OF BETA -THALASSEMIA ON LIVER ENZYMES AND RENAL FUNCTION.

B- Thalassemia major is characterized by highly faulty hemoglobin A Synthesis together with enhanced hemoglobin F manufacturing impaired red blood cell manufacturing and enhanced hemolysis of faulty red blood cells. β-Thalassaemia is discovered in Arab nations, particularly in Mediterranean nations, Saudi Arabia, Jordan, Syria and Yemen. Considered Bthalassemia the most prevalent monogenic disorder in the globe, affecting both sexes equally and placing patients and families at risk a serious health and financial burden. And both iron overload and chronic anemia in patients with b-thalassemia could explain tubular dysfunction and for liver fibrosis in transfusion-dependent thalassemia. This study aimed to study some biochemical variables of Thalassemia patients, where the effect of thalassemia on liver function and kidney function was studied. This study included 60 patients from (15 to 25) years of age of both sexes. The results were compared with (30) healthy subjects. We note in this study that most of the patients with thalassemia suffer from liver disease and malfunction in the functioning of the kidney because of the process of repeated blood transfusion where, we note there are significant differences when compared to healthy. A significant increase in the serum levels of AST, ALT and ALP was found in thalassaemia patients found significant alteration in liver functions of thalassemia patients. These patients may experience both tubular and glomerular dysfunction urea, creatinine and uric acid compared with healthy control. From this study, we can conclude that beta-thalassemia disease affects liver function and kidney function. [ABSTRACT FROM AUTHOR]