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Do sex-specific immunobiological factors and differences in angiotensin converting enzyme 2 (ACE2) expression explain increased severity and mortality of COVID-19 in males?
- Source :
- Diagnosis (2194-802X); Dec2020, Vol. 7 Issue 4, p385-386, 2p
- Publication Year :
- 2020
-
Abstract
- Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), shares similarities with the former SARS outbreak, which was caused by SARS-CoV-1. SARS was characterized by severe lung injury due to virus-induced cytopathic effects and dysregulated hyperinflammatory state. COVID-19 has a higher mortality rate in men both inside and outside China. In this opinion paper, we describe how sex-specific immunobiological factors and differences in angiotensin converting enzyme 2 (ACE2) expression may explain the increased severity and mortality of COVID-19 in males. We highlight that immunomodulatory treatment must be tailored to the underlying immunobiology at different stages of disease. Moreover, by investigating sex-based immunobiological differences, we may enhance our understanding of COVID-19 pathophysiology and facilitate improved immunomodulatory strategies. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANGIOTENSIN converting enzyme
SARS disease
COVID-19
SARS-CoV-2
Subjects
Details
- Language :
- English
- ISSN :
- 2194802X
- Volume :
- 7
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Diagnosis (2194-802X)
- Publication Type :
- Academic Journal
- Accession number :
- 147015390
- Full Text :
- https://doi.org/10.1515/dx-2020-0054