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Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients.
- Source :
- Journal of the Pediatric Infectious Diseases Society; Nov2020, Vol. 9 Issue 5, p622-625, 4p
- Publication Year :
- 2020
-
Abstract
- The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, we treated 2 patients with defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized. The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, 2 patients received defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved and hypofibrinolysis/complement activation normalized during treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- MULTISYSTEM inflammatory syndrome in children
PEDIATRICS
SARS disease
Subjects
Details
- Language :
- English
- ISSN :
- 20487193
- Volume :
- 9
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of the Pediatric Infectious Diseases Society
- Publication Type :
- Academic Journal
- Accession number :
- 147044104
- Full Text :
- https://doi.org/10.1093/jpids/piaa117