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Primary pneumococcal peritonitis can be the first presentation of a familial complement factor I deficiency1.

Authors :
Ugrinovic, S.
Firth, H.
Kavanagh, D.
Gouliouris, T.
Gurugama, P.
Baxendale, H.
Lachmann, P. J.
Kumararatne, D.
Gkrania‐Klotsas, E.
Source :
Clinical & Experimental Immunology; Dec2020, Vol. 202 Issue 3, p379-383, 5p, 1 Diagram, 1 Chart
Publication Year :
2020

Abstract

Summary: Primary pneumococcal peritonitis is a rare infection that has been described in women but has not been previously linked with immunodeficiency. The complement system plays a central role in immune defence against Streptococcus pneumoniae and, in order to evade complement attack, pneumococci have evolved a large number of mechanisms that limit complement‐mediated opsonization and subsequent phagocytosis. We investigated an apparently immunocompetent woman with primary pneumococcal peritonitis and identified a family with deficiency for complement factor I. Primary pneumococcal peritonitis should be considered a possible primary immunodeficiency presentation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00099104
Volume :
202
Issue :
3
Database :
Complementary Index
Journal :
Clinical & Experimental Immunology
Publication Type :
Academic Journal
Accession number :
147050085
Full Text :
https://doi.org/10.1111/cei.13490