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Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease.
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry; Oct2004, Vol. 75 Issue 10, p1472-1474, 3p
- Publication Year :
- 2004
-
Abstract
- <bold>Objective: </bold>Active or passive immunisation can mitigate plaque pathology in murine models of Alzheimer's disease (AD). Recently, it has been shown that antibodies against beta-amyloid (Abeta) are present in human immunoglobulin preparations (IVIgG), which specifically recognise and inhibit the neurotoxic effects of Abeta. This study reports the results from a pilot study using IVIgG in patients with AD.<bold>Methods: </bold>Five patients with AD were enrolled and received monthly IVIgG over a 6 month period. Efficacy assessment included total Abeta/Abeta(1-42) measured in the CSF/serum as well as effects on cognition (ADAS-cog; CERAD) at baseline and at 6 months following IVIgG.<bold>Results: </bold>Following IVIgG, total Abeta levels in the CSF decreased by 30.1% (17.3-43.5%) compared to baseline (p<0.05). Total Abeta increased in the serum by 233% (p<0.05). No significant change was found in Abeta(1-42) levels in the CSF/serum. Using ADAS-cog, an improvement of 3.7+/-2.9 points was detected. Scores in the MMSE were essentially unchanged (improved in four patients, stable in one patient) following IVIgG compared to baseline.<bold>Conclusion: </bold>Although the sample size of this pilot study is too small to draw a clear conclusion, the results of this pilot study provide evidence for a more detailed investigation of IVIgG for the treatment of AD. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALZHEIMER'S disease
IMMUNOGLOBULINS
NEUROTOXICOLOGY
PATIENTS
AMYLOID
PATHOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00223050
- Volume :
- 75
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 14730183
- Full Text :
- https://doi.org/10.1136/jnnp.2003.033399