The impact of chorionicity on pregnancy outcome and neurodevelopment at 2 years old among twins born preterm: the EPIPAGE-2 cohort study.

<bold>Objective: </bold>To compare the short- and mid-term outcomes of preterm twins by chorionicity of pregnancy.<bold>Design: </bold>Prospective nationwide population-based EPIPAGE-2 cohort study.<bold>Setting: </bold>546 maternity units in France, between March and December 2011.<bold>Population: </bold>A total of 1700 twin neonates born between 24 and 34 weeks of gestation.<bold>Methods: </bold>The association of chorionicity with outcomes was analysed using multivariate regression models.<bold>Main Outcome Measures: </bold>First, survival at 2-year corrected age with or without neurosensory impairment, and second, perinatal, short-, and mid-term outcomes (survival at discharge, survival at discharge without severe morbidity) were described and compared by chorionicity.<bold>Results: </bold>In the EPIPAGE 2 cohort, 1700 preterm births were included (850 twin pregnancies). In all, 1220 (71.8%) were from dichorionic (DC) pregnancies and 480 from monochorionic (MC) pregnancies. MC pregnancies had three times more medical terminations than DC pregnancies (1.67 versus 0.51%, P < 0.001), whereas there were three times more stillbirths in MC than in DC pregnancies (10.09 versus 3.78%, P < 0.001). Both twins were alive at birth in 86.6% of DC pregnancies compared with 80.0% among MC pregnancies (P = 0.008). No significant difference according to chorionicity was found regarding neonatal deaths and morbidities. Likewise, for children born earlier than 32 weeks, the 2-year follow-up neurodevelopmental results were not significantly different between DC and MC twins.<bold>Conclusions: </bold>This study confirms that MC pregnancies have a higher risk of adverse outcomes. However, the outcomes among preterm twins admitted to neonatal intensive care units are similar irrespective of chorionicity.<bold>Tweetable Abstract: </bold>Monochorionicity is associated with adverse perinatal outcomes, but outcomes for preterm twins are comparable irrespective of their chorionicity. [ABSTRACT FROM AUTHOR]