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Kinetic Resolution of 2‐N‐Acylamido Tertiary Allylic Alcohols: Asymmetric Synthesis of Oxazolines.
- Source :
- Advanced Synthesis & Catalysis; 1/5/2021, Vol. 363 Issue 1, p200-207, 8p
- Publication Year :
- 2021
-
Abstract
- A series of cyclohexyl‐fused SPINOL‐derived phosphoric acids (Cy‐SPA) have been developed to catalyze the kinetic resolution of 2‐N‐acylamido tertiary allylic alcohols, providing access to chiral oxazolines bearing C‐2 alkyl substituents with high enantioselectivities (with s‐factors up to 153). Gram‐scale reaction with 1 mol% catalyst loading and transformations of the chiral products demonstrates the value of these methods. [ABSTRACT FROM AUTHOR]
- Subjects :
- KINETIC resolution
ALLYL alcohol
ASYMMETRIC synthesis
PHOSPHORIC acid
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 363
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 147924481
- Full Text :
- https://doi.org/10.1002/adsc.202001051