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Indole alkaloid glycosides from Isatis tinctoria roots.
- Source :
- Natural Product Research; Jan2021, Vol. 35 Issue 2, p244-250, 7p
- Publication Year :
- 2021
-
Abstract
- Isatindigoside A and B (1 − 2), two new indole alkaloid glycosides along with five known ones (3 − 7) were obtained from the roots of I. tinctoria. Their structures were determined as isatindigoside A (1), isatindigoside B (2), isatindosulfonicacid A 3-O-β-D-glucopyranoside (3), indole-3-acetonitrile 6-O-β-D-glucopyranoside (4), isatindigobisindoloside A (5), isatindigobisindoloside B (6) isatindigobisindoloside F (7), by physicochemical properties and spectroscopic methods including 1 D, 2 D NMR, IR, HR-ESI-MS data. Nitric oxide (NO) inhibitory activities of all of the isolated compounds (1 − 7) were also evaluated. Compounds 2 and 7 showed inhibitory effects against LPS-stimulated RAW 264.7 cells with IC<subscript>50</subscript> values of 27.6 μM and 18.8 μM, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- INDOLE alkaloids
GLYCOSIDES
NITRIC oxide
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 35
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 147965446
- Full Text :
- https://doi.org/10.1080/14786419.2019.1624960