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Four new neo-clerodane diterpenes from the stem bark of Croton oligandrus.
- Source :
- Natural Product Research; Jan2021, Vol. 35 Issue 2, p298-304, 7p
- Publication Year :
- 2021
-
Abstract
- Four new neo-clerodanes, crotonolins C-F (3-6), were isolated from the stem bark of Croton oligandrus together with the known clerodane crotonzambefuran A, the abietanes 7-β-hydroxydehydroabietic acid and 7-oxodehydroabietic acid, and ferulic acid. Their structures were elucidated by spectroscopic analyses including 1D and 2D NMR and HRESIMS and by comparison with previously reported data. The cytotoxicity of the isolated compounds against A549, MCF7, PC3 and PNT2 cells was evaluated using the MTT assay. Only 7-β-hydroxydehydroabietic acid showed a moderate level of activity against PC3 cells with an IC<subscript>50</subscript> value of 68.9 ± 6.6 µM. [ABSTRACT FROM AUTHOR]
- Subjects :
- DITERPENES
BARK
FERULIC acid
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 35
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 147965454
- Full Text :
- https://doi.org/10.1080/14786419.2019.1628745