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Absence of heparan sulfate proteoglycans in Lewy bodies and Lewy neurites in Parkinson's disease brains.
- Source :
- Journal of Alzheimer's Disease; 2004, Vol. 6 Issue 5, p469-474, 6p, 1 Color Photograph
- Publication Year :
- 2004
-
Abstract
- alpha-Synuclein is the major constituent of Lewy bodies and Lewy neurites in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Relatively little is known about the exact mechanism of alpha-synuclein deposition and fibrillization in these alpha-synucleinopathies. In order to better understand the pathogenesis of alpha-synucleinopathies it is important to identify molecules that regulate the fibrillization of alpha-synuclein. Since it has been demonstrated that heparan sulfate proteoglycans (HSPGs) and glycosaminoglycans (GAGs) promote the conversion of non-fibrillar amyloid beta-protein (Abeta) into neurotoxic fibrillar Abeta in Alzheimer's disease, they might also be involved in alpha-synuclein aggregation. It was the aim of our study to examine the distribution pattern of these macromolecules in PD brains and the possible association with Lewy bodies and Lewy neurites. Although HSPGs clearly colocalized with senile plaques, we were unable to identify HSPGs or GAGs in Lewy bodies and Lewy neurites and therefore concluded that it is likely that alpha-synuclein fibrillization and stabilization occurs independently of the presence of HSPGs or GAGs. [ABSTRACT FROM AUTHOR]
- Subjects :
- LEWY body dementia
PARKINSON'S disease
PROTEOGLYCANS
MACROMOLECULES
GLYCOSAMINOGLYCANS
BRAIN metabolism
BRAIN
CELL physiology
COMPARATIVE studies
IMMUNOHISTOCHEMISTRY
LIMBIC system
RESEARCH methodology
MEDICAL cooperation
MONOCLONAL antibodies
NERVE tissue proteins
NEURONS
POLYSACCHARIDES
RESEARCH
EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 6
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 14797304
- Full Text :
- https://doi.org/10.3233/JAD-2004-6502