Non-Rigid Respiratory Motion Estimation of Whole-Heart Coronary MR Images Using Unsupervised Deep Learning.

Non-rigid motion-corrected reconstruction has been proposed to account for the complex motion of the heart in free-breathing 3D coronary magnetic resonance angiography (CMRA). This reconstruction framework requires efficient and accurate estimation of non-rigid motion fields from undersampled images at different respiratory positions (or bins). However, state-of-the-art registration methods can be time-consuming. This article presents a novel unsupervised deep learning-based strategy for fast estimation of inter-bin 3D non-rigid respiratory motion fields for motion-corrected free-breathing CMRA. The proposed 3D respiratory motion estimation network (RespME-net) is trained as a deep encoder-decoder network, taking pairs of 3D image patches extracted from CMRA volumes as input and outputting the motion field between image patches. Using image warping by the estimated motion field, a loss function that imposes image similarity and motion smoothness is adopted to enable training without ground truth motion field. RespME-net is trained patch-wise to circumvent the challenges of training a 3D network volume-wise which requires large amounts of GPU memory and 3D datasets. We perform 5-fold cross-validation with 45 CMRA datasets and demonstrate that RespME-net can predict 3D non-rigid motion fields with subpixel accuracy (0.44 ± 0.38 mm) within ~10 seconds, being ~20 times faster than a GPU-implemented state-of-the-art non-rigid registration method. Moreover, we perform non-rigid motion-compensated CMRA reconstruction for 9 additional patients. The proposed RespME-net has achieved similar motion-corrected CMRA image quality to the conventional registration method regarding coronary artery length and sharpness. [ABSTRACT FROM AUTHOR]